From State-Owned Enterprise to Joint Venture: A Case Study of the Crisis in Urban Social Services

This is a publisher's version of an article published in The China Journal in 2000. The offprint is posted here in accordance with existing publisher policy, or by special permission via correspondence.tru

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery

Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD). Mounting evidence supports that HDLs are atheroprotective, therefore, many therapeutic approaches have been developed to increase HDL cholesterol (HDL-C) levels. Nevertheless, HDL-raising therapies, such as cholesteryl ester transfer protein (CETP) inhibitors, failed to ameliorate cardiovascular outcomes in clinical trials, thereby casting doubt on the treatment of cardiovascular disease (CVD) by increasing HDL-C levels. Therefore, HDL-targeted interventional studies were shifted to increasing the number of HDL particles capable of promoting ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux. One such approach was the development of reconstituted HDL (rHDL) particles that promote ABCA1-mediated cholesterol efflux from lipid-enriched macrophages. Here, we explore the manipulation of rHDL nanoparticles as a strategy for the treatment of CVD. In addition, we discuss technological capabilities and the challenge of relating preclinical in vivo mice research to clinical studies. Finally, by drawing lessons from developing rHDL nanoparticles, we also incorporate the viabilities and advantages of the development of a molecular imaging probe with HDL nanoparticles when applied to ASCVD, as well as gaps in technology and knowledge required for putting the HDL-targeted therapeutics into full gear

Relative camera pose estimation method using optimization on the manifold

To solve the problem of relative camera pose estimation, a method using optimization with respect to the manifold is proposed. Firstly from maximum-a-posteriori (MAP) model to nonlinear least squares (NLS) model, the general state estimation model using optimization is derived. Then the camera pose estimation model is applied to the general state estimation model, while the parameterization of rigid body transformation is represented by Lie group/algebra. The jacobian of point-pose model with respect to Lie group/algebra is derived in detail and thus the optimization model of rigid body transformation is established. Experimental results show that compared with the original algorithms, the approaches with optimization can obtain higher accuracy both in rotation and translation, while avoiding the singularity of Euler angle parameterization of rotation. Thus the proposed method can estimate relative camera pose with high accuracy and robustness

Modification of the fatty acid composition in Arabidopsis and maize seeds using a stearoyl-acyl carrier protein desaturase-1 (ZmSAD1) gene

Composition of fatty acids in the transgenic ZmSAD1 Arabidopsis mature seeds (DOCX 17 kb

What Affects Chinese Residents’ Perceptions of Climate Change?

The theme of global sustainable development has changed from environmental management to climate governance, and relevant policies on climate governance urgently need to be implemented by the public. The public understanding of climate change has become the prerequisite and basis for implementing various climate change policies. In order to explore the affected factors of climate change perception among Chinese residents, this study was conducted across 31 provinces and regions of China through field household surveys and interviews. Combined with the residents&rsquo; perception of climate change with the possible affected factors, the related factors affecting Chinese residents&rsquo; perception of climate change were explored. The results show that the perceptive level of climate change of Chinese residents is related to the education level and the household size of residents. Improving public awareness of climate change risk in the context of climate change through multiple channels will also help to improve residents&rsquo; awareness of climate change. On the premise of improving the level of national education, improving education on climate change in school education and raising awareness of climate change risk among dependents will help to improve the level of Chinese residents&rsquo; awareness of climate change, which could be instrumental in promoting public participation in climate change mitigation an dadaptation actions</p